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GRACE Checklist

While the demand for information about comparative effectiveness is growing exponentially, there is little understanding about how to recognize non-interventional studies that are good enough for decision support. An 11-item checklist was developed and validated to help select robust observational research of comparative effectiveness that merit serious consideration for their information value.

Checklist items were compiled through literature review and consultation with experts from academia and other health professionals. Since no gold standard exists for this application, three validation tests were used to evaluate checklist items:

  1. Quality assessments from published systematic reviews
  2. Individual recognized experts
  3. Concordant expert assessments

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